تفاعل #49355

معادلة التفاعل

4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-methoxy-7-iodoisoindolinone

المردود 78.0%

المذيبات

nitromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe obtained solid was collected by filtration
2. 2
   غسيلwashed with ethyl acetate
3. 3
   أخرىThe obtained solid was dried under reduced pressure

الإجراء التجريبي

In a similar manner to Step 4 of Example 16, 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (2.50 g, 5.91 mmol) was dissolved in nitromethane (100 mL), and the solution was treated with trifluoroacetic acid (4.50 mL, 59.1 mmol) and triethylsilane (1.90 mL, 11.8 mmol). The obtained solid was collected by filtration and washed with ethyl acetate. The obtained solid was dried under reduced pressure to obtain 4-methoxy-7-iodoisoindolinone (1.32 g, yield 78%).

المصدر