تفاعل #49348

معادلة التفاعل

cumylamine

triethylamine

3-fluorobenzoyl chloride

→

3-fluoro-N-(1-methyl-1-phenylethyl)benzamide

المردود 95.3%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was purified by slurry

الإجراء التجريبي

In a similar manner to Step 1 of Example 16, 3-fluorobenzoyl chloride (2.00 g, 12.6 mmol) was dissolved in dichloromethane (40 mL), and the solution was treated with cumylamine (1.99 mL, 13.9 mmol), triethylamine (2.63 mL, 18.9 mmol) and DMAP (154 mg, 1.26 mmol). The mixture was purified by slurry using diisopropylether to obtain 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide (3.09 g, yield 95%).

المصدر