تفاعل #492293

معادلة التفاعل

NaOH

THF

ethyl 3-(5-(2-(([1,1′-biphenyl]-4-ylamino)methyl)phenyl)picolinamido)propanoate

→

title compound

3-(5-(2-(([1,1′-biphenyl]-4-ylamino)methyl)phenyl)picolinamido)propanoic acid

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter 3 h the resulting mixture was concentrated in vacuo
2. 2
   ترشيحThe resulting precipitate was filtered off
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

A 3M aqueous solution of NaOH (0.1 mL, 0.30 mmol) was added to a THF (1 mL) and MeOH (0.5 mL) solution of ethyl 3-(5-(2-(([1,1′-biphenyl]-4-ylamino)methyl)phenyl)picolinamido)propanoate (73 mg, 0.15 mmol) and the homogeneous mixture was stirred at room temperature. After 3 h the resulting mixture was concentrated in vacuo, suspended in water, and acidified with 2M HCl. The resulting precipitate was filtered off and dried in vacuo to yield the title compound.

المصدر