تفاعل #49172

معادلة التفاعل

Compound 4a

(6-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-6-oxo-hexyl)-carbamic acid benzyl ester

→

compound 5

المردود 91.4%

6-Amino-1-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-hexan-1-one

المردود 91.4%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىpurged with argon
2. 2
   workup.ADDITIONTo the solution was added 10% palladium on carbon (2 g)
3. 3
   أخرىThe flask was purged with hydrogen 2 times
4. 4
   ترشيحThe reaction mixture was filtered through a pad of Celite
5. 5
   غسيلwashed with ethyl acetate
6. 6
   تركيزThe combined organic layer was concentrated under reduced pressure

الإجراء التجريبي

Compound 4a (14.5 g, 21.7 mmol) was dissolved in ethyl acetate (100 mL) and purged with argon. To the solution was added 10% palladium on carbon (2 g). The flask was purged with hydrogen 2 times and stirred further at room temperature under hydrogen atmosphere for overnight. The disappearance of the starting material was confirmed by the TLC. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate. The combined organic layer was concentrated under reduced pressure to afford compound 5 (10.56 g, 91%) as white solid. This was used as such for the next step.

المصدر