تفاعل #49101

معادلة التفاعل

D1

1-(dimethylamino)cyclopentanecarbonitrile

dihydro-3(2H)-furanone

dimethylamine hydrochloride

potassium cyanide

→

title compound

المردود 88.0%

(±)-3-(Dimethylamino)tetrahydro-3-furancarbonitrile

المردود 88.0%

المذيبات

water

ظروف التفاعل

الإجراء التجريبي

The title compound (6.54 g, 88%) was prepared from dihydro-3(2H)-furanone D44 (4.54 g, 0.053 mol), dimethylamine hydrochloride (4.9 g, 0.06 mol) and potassium cyanide (3.5 g, 0.054 mol) in water (100 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 2.15 (1H, m), 2.33 (6H, s), 2.44 (1H, m), 3.69 (1H, d), 4.02-4.13 (2H, m), 4.17 (1H, m).

المصدر