تفاعل #49099

معادلة التفاعل

sodium borohydride

2-(hexahydro-1H-azepin-1-yl)-2-methylpropanenitrile

phenyllithium

D5

[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine

→

title compound

المردود 83.0%

(±)[2-(Hexahydro-1H-azepin-1-yl)-2-methyl-1-phenylpropyl]amine

المردود 83.0%

المذيبات

THF

methanol

dibutylether

ظروف التفاعل

الإجراء التجريبي

The title compound (3.7 g; 83%) was prepared from 2-(hexahydro-1H-azepin-1-yl)-2-methylpropanenitrile D41 (3 g; 18 mmol) and phenyllithium in dibutylether (18 ml of a 2M solution; 36 mmol) in THF (100 ml), followed by reaction with sodium borohydride (2.13 g, 54 mmol) in methanol (100 ml) in a similar manner to that described in D5. 1H NMR (CDCl3) δ 0.78 (3H, s), 0.98 (3H, s), 1.55-1.70 (8H, m), 1.83 (2H, br s), 2.67-2.79 (4H, m), 4.18 (1H, s), 7.20-7.30 (3H, m), 7.40-7.42 (2H, m).

المصدر