تفاعل #49098

معادلة التفاعل

D1

1-(dimethylamino)cyclopentanecarbonitrile

homopiperidine hydrochloride

acetone

potassium cyanide

→

title compound

المردود 80.0%

2-(Hexahydro-1H-azepin-1-yl)-2-methylpropanenitrile

المردود 80.0%

المذيبات

water

ظروف التفاعل

الإجراء التجريبي

The title compound (6.6 g: 80%) was prepared from homopiperidine hydrochloride (6.7 g; 49 mmol), acetone (3.67 ml; 50 mmol), and potassium cyanide (3.25 g; 50 mmol) in water (25 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ 1.43 (6H, s), 1.50-1.65 (8H, m), 2.66 (4H, m).

المصدر