تفاعل #49096

معادلة التفاعل

cyclopentanone

2-methylpyrrolidine

potassium cyanide

→

title compound

المردود 79.0%

(±)-1-(2-Methyl-1-pyrrolidinyl)cyclopentanecarbonitrile

المردود 79.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىpartitioned between ethyl acetate and water
2. 2
   تجفيفThe organic layer was dried (Na2SO4)
3. 3
   أخرىevaporated in vacuo

الإجراء التجريبي

A mixture of cyclopentanone (1.34 g, 16 mmol) and 2-methylpyrrolidine (1.36 g; 16 mmol) was cooled to 0° C. (ice bath). A solution of potassium cyanide (1.04 g, 16 mmol) in water (10 ml) was added dropwise over 10 min and the whole mixture stirred vigorously for 18 h at 20° C., and then partitioned between ethyl acetate and water. The organic layer was dried (Na2SO4) and evaporated in vacuo to afford the title compound (2.24 g; 79%). 1NMR (CDCl3) δ: 1.1 (3H, d), 1.45 (1H, m), 1.75-2.05 (9H, m), 2.13 (2H, m), 2.65 (1H, m), 3.1 (2H, m).

المصدر