تفاعل #49095

معادلة التفاعل

1-(2,5-dihydro-1H-pyrrol-1-yl)cyclopentanecarbonitrile

phenyllithium

di-n-butylether

sodium borohydride

D2

Racemic {1-[amino(phenyl)methyl]cyclopentyl}dimethylamine

→

title compound

المردود 45.0%

(±)-[[1-(2,5-Dihydro-1H-pyrrol-1-yl)cyclopentyl](phenyl)methyl]amine

المردود 45.0%

المذيبات

THF

methanol

ظروف التفاعل

الإجراء التجريبي

The title compound (1.35 g; 45%) was prepared from 1-(2,5-dihydro-1H-pyrrol-1-yl)cyclopentanecarbonitrile D37 (2.0 g; 12.3 mmol), and phenyllithium in di-n-butylether (7.5 ml of 1.8M solution; 13.5 mmol) in THF (20 ml), followed by reaction with sodium borohydride (1.402 g; 36.9 mmol) in methanol (20 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS): Found 243 (MH+). C16H22N2 requires 242. Ret. time 1.02 min.

المصدر