تفاعل #49093

معادلة التفاعل

1-{methyl[2-(methyloxy)ethyl]amino}cyclopentanecarbonitrile

phenyllithium

di-n-butylether

sodium borohydride

D2

Racemic {1-[amino(phenyl)methyl]cyclopentyl}dimethylamine

→

title compound

المردود 42.0%

(±)-{1-[Amino(phenyl)methyl]cyclopentyl}methyl[2-(methyloxy)ethyl]amine

المردود 42.0%

المذيبات

THF

methanol

ظروف التفاعل

الإجراء التجريبي

The title compound (1.22 g; 42%) was prepared from 1-{methyl[2-(methyloxy)ethyl]amino}cyclopentanecarbonitrile D35 (2.0 g; 11 mmol), and phenyllithium in di-n-butylether (6.7 ml of 1.8M solution; 12 mmol) in THF (25 ml), followed by reaction with sodium borohydride (1.25 g; 33 mmol) in methanol (25 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS). Found 263 (MH+). C16H26N2O requires 262. Ret. time 1.57 min.

المصدر