تفاعل #49077

معادلة التفاعل

sodium borohydride

2-ethyl-2-(1-pyrrolidinyl)butanenitrile

phenyllithium

D5

[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine

→

title compound

المردود 88.0%

(±)[2-Ethyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine

المردود 88.0%

المذيبات

THF

methanol

dibutylether

ظروف التفاعل

الإجراء التجريبي

The title compound (11.5 g, 88%) was prepared from 2-ethyl-2-(1-pyrrolidinyl)butanenitrile D17 (8.8 g, 0.053 mol) and phenyllithium in dibutylether (59 ml of a 1.8M solution; 0.106 mol) in THF (350 ml), followed by reaction with sodium borohydride (3.9 g, 0.103 mol) in methanol (300 ml) in a similar manner to that described in D5. 1H NMR (CDCl3) δ: 0.75 (3H, t), 0.95 (3H, t, J=7.6 Hz), 1.50-1.90 (10H, m), 2.70-2.95 (4H, m), 4.01 (1H, s), 7.19-7.41 (5H, m).

المصدر