تفاعل #49040

معادلة التفاعل

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

methylamine

→

title compound

3-aminooxy-2,2,N-trimethyl-propionamide

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter the reaction mixture was concentrated under reduced pressure, dichloromethane
2. 2
   workup.ADDITIONwas added to the residue, and insoluble matter
3. 3
   ترشيحwas filtered
4. 4
   تركيزThe filtrate was concentrated
5. 5
   أخرىthe residue was purified by silica gel column chromatography

الإجراء التجريبي

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

المصدر