تفاعل #49039

معادلة التفاعل

diisopropyl azodicarboxylate

methyl hydroxypivalate

hydroxyphthalimide

triphenylphosphine

→

title compound

المردود 33.6%

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

المردود 33.6%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto warm gradually
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe residue was roughly purified by silica gel column chromatography

الإجراء التجريبي

To methyl hydroxypivalate (1.31 g, 9.89 mmol) were added tetrahydrofuran (40 ml), hydroxyphthalimide (3.23 g, 19.78 mmol) and triphenylphosphine (6.48 g, 24.73 mmol). After this solution was cooled to 0° C., diisopropyl azodicarboxylate (4.87 ml, 24.73 mmol) was added dropwise to the solution. While being allowed to warm gradually, the reaction mixture was stirred for 12 hours, and concentrated under reduced pressure. The residue was roughly purified by silica gel column chromatography to give the title compound (922 mg).

المصدر