تفاعل #489644

معادلة التفاعل

2-chloro-6-methylisonicotinic acid

ammonia

sodium sulphide

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2-amino-6-methylisonicotinic acid

المذيبات

water

ظروف التفاعل

الإجراء التجريبي

2-chloro-6-methylisonicotinic acid (9 g), of aq ammonia (44 ml), of Cu(II)SO4 (0.9 g) and of sodium sulphide (0.32 g) are added to an autoclave and heated to 155° C. overnight. The crude product is suspended in water to yield 2-amino-6-methylisonicotinic acid (3.6 g). HPLC: Rt=0.37 min (method D)

المصدر