تفاعل #489363

معادلة التفاعل

cyclohexanecarbothioic acid amide

ethyl 3-bromopyruvate

→

title compound 116

المردود 74.2%

2-cyclohexylthiazole-4-carboxylic acid ethyl ester

المردود 74.2%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThen, the solvent was evaporated
2. 2
   أخرىthe residue was purified by column chromatography (gradient of heptane/AcOEt, 90:10 to 75:25)

الإجراء التجريبي

A solution of cyclohexanecarbothioic acid amide (115, 5.5 g, 38.3 mmol) and ethyl 3-bromopyruvate (90%, 8.3 g, 38.3 mmol) in THF (200 mL) was heated to reflux. After 2 h, the reaction mixture was cooled to room temperature for 12 h. Then, the solvent was evaporated and the residue was purified by column chromatography (gradient of heptane/AcOEt, 90:10 to 75:25) to afford 6.8 g (74%) of the title compound 116 as a clear liquid.

المصدر