تفاعل #48920

معادلة التفاعل

4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

Selectfluor

→

4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىpurified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate)

الإجراء التجريبي

A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.

المصدر