تفاعل #48864

معادلة التفاعل

tert-butyl 3-[(3-(benzyloxy)-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

→

crude solid

المردود 91.1%

tert-Butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

المردود 91.1%

المذيبات

THF ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas evacuated
2. 2
   أخرىpurged with nitrogen (×3)
3. 3
   workup.ADDITION10% Palladium on carbon was added
4. 4
   أخرىthe reaction mixture was evacuated
5. 5
   أخرىpurged with nitrogen
6. 6
   أخرىevacuated
7. 7
   أخرىfinally purged with hydrogen gas
8. 8
   workup.WAITThe reaction mixture was left
9. 9
   ترشيحThe Palladium catalyst was filtered through diatomaceous earth
10. 10
    أخرىThe filtrate was evaporated

الإجراء التجريبي

A solution of tert-butyl 3-[(3-(benzyloxy)-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate (90 mg, 0.144-mmol) in 1:1 mixture of THF/ethanol was evacuated and purged with nitrogen (×3). 10% Palladium on carbon was added and the reaction mixture was evacuated and purged with nitrogen and then evacuated and finally purged with hydrogen gas. The reaction mixture was left to stir at ambient temperature under an atmosphere of hydrogen for 6 hours. The Palladium catalyst was filtered through diatomaceous earth. The filtrate was evaporated to give a crude solid (70 mg)

المصدر