تفاعل #48832

معادلة التفاعل

2,4,5-Trifluorophenyl sulfonyl chloride

sodium sulfite

sodium bicarbonate

bromoacetic acid

→

desired compound

المردود 66.5%

1,2,4-Trifluoro-5-(methylsulfonyl)benzene

المردود 66.5%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   درجة الحرارةheated to 150° C. for 300 seconds
3. 3
   درجة الحرارةto cool
4. 4
   أخرىwas removed by filtration
5. 5
   أخرىdried in vacuo

الإجراء التجريبي

2,4,5-Trifluorophenyl sulfonyl chloride (279 mg) was added to a solution of sodium sulfite (306 mg) and sodium bicarbonate (153 mg) in water (4 mL). The mixture was heated to 150° C. in a sealed microwave vial for 400 seconds and allowed to cool. The mixture was treated with bromoacetic acid (253 mg) in water (1 mL), and heated to 150° C. for 300 seconds then allowed to cool, following which the precipitate was removed by filtration and dried in vacuo to give the desired compound (169 mg). The material was used without further purification. 1H NMR δ (d6-DMSO): 3.35 (s, 3H), 7.87-8.01 (m, 2H).

المصدر