تفاعل #487543

معادلة التفاعل

2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine

methyl 4-amino-2-(3-chloropropoxy)benzoate

→

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-2-(3-chloropropoxy)benzoate

المذيبات

THF

DCM

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was collected
2. 2
   تجفيفdried over sodium sulfate
3. 3
   تركيزconcentrated under vacuum
4. 4
   أخرىThe crude product was purified by silica gel chromatography
5. 5
   أخرىThe product fractions were collected
6. 6
   تركيزconcentrated under vacuum

الإجراء التجريبي

To a solution of 2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine (770 mg, 2.79 mmol) in THF (10 mL) was added methyl 4-amino-2-(3-chloropropoxy)benzoate (681 mg, 2.79 mmol) and Hunig'sBase (1.464 mL, 8.38 mmol). The resulting mixture was stirred for 16 h. The reaction was diluted with DCM and water. The organic layer was collected and dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by silica gel chromatography using 20-40% EtOAc/Hexanes. The product fractions were collected and concentrated under vacuum to give methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-2-(3-chloropropoxy)benzoate as a solid.

المصدر