تفاعل #4872

معادلة التفاعل

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

المردود 75.1%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is refluxed for 30 minutes
2. 2
   درجة الحرارةunder heating
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىcrystalline precipitates
5. 5
   ترشيحare collected by filtration
6. 6
   غسيلwashed with methanol
7. 7
   أخرىCrystalline precipitates
8. 8
   ترشيحare collected by filtration
9. 9
   أخرىdried

الإجراء التجريبي

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

المصدر