تفاعل #48689

معادلة التفاعل

trifluoromethanesulphonic anhydride

neopentylalcohol

2,6-lutidine

→

desired compound

المردود 72.0%

Trifluoromethanesulfonic acid 2,2-dimethylpropyl ester

المردود 72.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAdd water to quench
2. 2
   أخرىthe reaction
3. 3
   أخرىseparate the organic layer
4. 4
   استخلاصextract the aqueous layer with dichloromethane
5. 5
   تجفيفdry (magnesium sulfate)
6. 6
   ترشيحfilter
7. 7
   تركيزconcentrate
8. 8
   أخرىpurify
9. 9
   غسيل(silica gel chromatography, eluting with 1:4 hexane:dichloromethane)

الإجراء التجريبي

Add trifluoromethanesulphonic anhydride (1.12 mL, 6.8 mmol) to a solution of neopentylalcohol (0.5 g, 5.7 mmol) and 2,6-lutidine (0.7 mL, 6.8 mmol) in dichloromethane (10 mL) at −78° C. and stir for 1 hour. Add water to quench the reaction, separate the organic layer and extract the aqueous layer with dichloromethane. Combine the organic layers, dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 1:4 hexane:dichloromethane) to give the desired compound as an oil (0.9 g, 72% yield).

المصدر