تفاعل #486524

معادلة التفاعل

N-(t-Butyloxy)-2-(R)-[(4-methoxybenzenesulfonyl)(4-picolyl)amino]-2-[(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide

methylene chloride

ethanol

→

N-hydroxy-2-(R)-[(4-methoxy-benzenesulfonyl) (4-picolyl)amino]-2- [(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىHydrochloric acid gas (from a lecture bottle) is bubbled trough the solution for 15 minutes
2. 2
   أخرىThe flask is sealed
3. 3
   درجة الحرارةto slowly warm to room temperature
4. 4
   تركيزThe reaction mixture is concentrated in vacuo

الإجراء التجريبي

N-(t-Butyloxy)-2-(R)-[(4-methoxybenzenesulfonyl)(4-picolyl)amino]-2-[(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide (3 g, 4.65 mmol) is dissolved in methylene chloride (100 ml) containing ethanol (0.27 ml, 4.6 mmol) and the reaction mixture is cooled to -10° C. Hydrochloric acid gas (from a lecture bottle) is bubbled trough the solution for 15 minutes. The flask is sealed, the reaction mixture is allowed to slowly warm to room temperature and stirred at room temperature for 6 days. The reaction mixture is concentrated in vacuo to provide N-hydroxy-2-(R)-[(4-methoxy-benzenesulfonyl) (4-picolyl)amino]-2- [(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide hydrochloride as a white solid, m.p. >137° C. (dec).

المصدر