تفاعل #4862

معادلة التفاعل

2-bromo-m-xylene

N-allylphthalimide

acetate

triphenylphosphine

→

2-[3-(2,6-dimethylphenyl)-2-propenyl]-1H-isoindole-1,3(2H)-dione

المذيبات

triethylamine

ether

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe aqueous layer was separated
2. 2
   غسيلthe organic washed twice with 100 ml portions of 2N HCl
3. 3
   ترشيحAfter filtering the organic phase
4. 4
   غسيلwashing with saturated KHCO3 and brine
5. 5
   تجفيفdrying over MgSO4, it
6. 6
   تركيزwas concentrated on the steam bath
7. 7
   أخرىThe resulting solid product was purified by flash chromotography

الإجراء التجريبي

A mixture 9.3 g (50 mmole) of 2-bromo-m-xylene, 15.0 g (80 mmole) of N-allylphthalimide, 0.56 (2.5 mmole) of paladium acetate and 1.44 (5.5 mmole) of triphenylphosphine were dissolved in 111 ml of triethylamine. The solution was placed in a sealed container and heated at 100° C. for 24 hours. The reaction was then diluted with 800 ml of ether and 200 ml of water. The aqueous layer was separated and the organic washed twice with 100 ml portions of 2N HCl. After filtering the organic phase, washing with saturated KHCO3 and brine, and drying over MgSO4, it was concentrated on the steam bath. The resulting solid product was purified by flash chromotography and used in subsequent reactions.

المصدر