تفاعل #48608

معادلة التفاعل

2-(2-fluorophenyl)-ethanol

vinyl acetate

sodium carbonate

→

title compound

المردود 72.2%

1-Fluoro-2-(2-vinyloxyethyl)-benzene

المردود 72.2%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةCool the reaction mixture to room temperature
2. 2
   ترشيحVacuum filter the resultant slurry
3. 3
   أخرىto remove inorganic precipitates
4. 4
   غسيلwashing the collected solid with hexanes
5. 5
   تركيزConcentrate
6. 6
   أخرىpurify
7. 7
   غسيل(silica gel chromatography, eluting with hexanes)

الإجراء التجريبي

Combine 2-(2-fluorophenyl)-ethanol (3.08 g, 22.0 mmol), vinyl acetate (4 mL, 43.3 mmol), anhydrous toluene (22 mL), chloro(1,5-cyclooctadiene)iridium(I) dimer (155 mg, 0.231 mmol), and anhydrous sodium carbonate (1.5 g, 14.2 mmol) in a dry round-bottom flask fitted with a reflux condensor under a nitrogen atmosphere. Heat the resulting mixture to 95° C. for 5 hours. Cool the reaction mixture to room temperature. Vacuum filter the resultant slurry to remove inorganic precipitates, washing the collected solid with hexanes. Concentrate and purify (silica gel chromatography, eluting with hexanes) to give the title compound as a yellow oil (2.64 g, 72%).

المصدر