تفاعل #48596

معادلة التفاعل

4-phenyl-1H-pyrazole-3-carboxylic acid

aniline

EDAC

HOBt

→

4-phenyl-1H-pyrazole-3-carboxylic acid phenylamide

المردود 28.5%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was evaporated
2. 2
   أخرىthen purified by flash column chromatography
3. 3
   غسيلeluting with 1:3
4. 4
   workup.ADDITIONProduct containing fractions
5. 5
   أخرىevaporated

الإجراء التجريبي

A solution of 4-phenyl-1H-pyrazole-3-carboxylic acid (75 mg; 0.4 mmol) (prepared according to Example 228C), aniline (45 μl; 0.48 mmol), EDAC (92 mg; 0.48 mmol) and HOBt (65 mg; 0.48 mmol) in 5 ml of DMF was stirred at room temperature overnight. The reaction was evaporated then purified by flash column chromatography eluting with 1:3 then 1:2 ethyl acetate/hexane. Product containing fractions were combined and evaporated to give 30 mg of 4-phenyl-1H-pyrazole-3-carboxylic acid phenylamide as a white solid. (LC/MS: Rt 3.12 [M+H]+ 264).

المصدر