تفاعل #48585

معادلة التفاعل

Thionyl chloride

4-nitro-3-pyrazolecarboxylic acid

EtOH

→

4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester

المردود 96.0%

ظروف التفاعل

المعالجة

1. 1
   تجفيفdried through azeotrope with toluene

الإجراء التجريبي

Thionyl chloride (2.90 ml, 39.8 mmol) was slowly added to a mixture of 4-nitro-3-pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in EtOH (100 ml) at ambient temperature and the mixture stirred for 48 h. The mixture was reduced in vacuo and dried through azeotrope with toluene to afford 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester as a white solid (6.42 g, 96%). (1H NMR (400 MHz, DMSO-d6) δ 14.4 (s, 1H), 9.0 (s, 1H), 4.4 (q, 2H), 1.3 (t, 3H)).

المصدر