تفاعل #4854

معادلة التفاعل

2,3-dihydro-5,7-dinitro-2-methylbenzofuran

ammonia

Methyl Cellosolve

→

expected product

1-(2-amino-3,5-dinitrophenyl)-2-propanol

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture is cooled
2. 2
   أخرىThe precipitate formed
3. 3
   أخرىthen dried under vacuum
4. 4
   أخرىis recrystallized from 170 ml of dioxane
5. 5
   أخرىAfter being dried under vacuum

الإجراء التجريبي

0.39 Mole (88 g) of 2,3-dihydro-5,7-dinitro-2-methylbenzofuran, prepared according to J.A.C.S. 80, p. 4711-4714 (1958), is suspended in 1.1 l of 20% strength ammonia solution and 600 ml of Methyl Cellosolve. After 18 hours' heating at 70° C., the reaction mixture is cooled. The precipitate formed is drained and, after being made into a paste in water until neutral and then dried under vacuum, is recrystallized from 170 ml of dioxane. After being dried under vacuum, 0.30 mole (72 g) of the expected product is obtained; it melts at 177° C.

المصدر