تفاعل #484329

معادلة التفاعل

2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline

potassium carbonate

tetrabutylammonium tribromide

→

4-bromo-2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحFor work-up, the solid is filtered off with suction
2. 2
   workup.ADDITIONthe solution is diluted with methylene chloride
3. 3
   استخلاصextracted with water
4. 4
   غسيلwashed twice with water
5. 5
   أخرىThe organic phase is dried
6. 6
   تركيزconcentrated

الإجراء التجريبي

30 g (170 mmol) of 2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline are dissolved in 400 ml of acetonitrile, and 94 g (0.68 mol) of potassium carbonate are added. At temperatures <30° C., 84 g (174 mmol) of tetrabutylammonium tribromide are then added a little at a time, with vigorous stirring. For work-up, the solid is filtered off with suction and the solution is diluted with methylene chloride and extracted with water. The solvent is stripped off and the residue is then taken up again in methyl tert-butyl ether and washed twice with water. The organic phase is dried and concentrated.

المصدر