تفاعل #483557

معادلة التفاعل

2-methylthio4-iodopyrimidine

2-(4-fluorophenyl)-5-aminoimidazo[4,5-b]pyridine

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crude product

2-(4-Fluorophenyl)-1-(2-methylthio-4-pyrimidinyl)-5-aminoimidazo[4,5-b]pyridine

المذيبات

toluene

toluene

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated for 18 h at 120° C
2. 2
   workup.ADDITIONThe reaction mixture is poured on water
3. 3
   استخلاصextracted with ethyl acetate three times
4. 4
   تجفيفThe combined organic phases are dried over Na2SO4
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated to dryness

الإجراء التجريبي

KN(TMS)2 (688 mg 3.65 mmol) in toluene (3.5 ml) is added at 0° C. to a solution of 2-(4-fluorophenyl)-5-aminoimidazo[4,5-b]pyridine (684 mg 3 mmol) in DMF (10 ml). After stirring 1 h at room temperature, 2-methylthio4-iodopyrimidine (832 mg 3.3 mmol) in toluene (3.3 ml) is added dropwise and heated for 18 h at 120° C. The reaction mixture is poured on water and extracted with ethyl acetate three times. The combined organic phases are dried over Na2SO4, filtered and evaporated to dryness to yield the crude product, which is purified by SiO2 chromatography (acetone/cyclohexane 20/80 to 60/40) and renders the title compound as a yellow foam (300 mg 27%)

المصدر