تفاعل #4835

معادلة التفاعل

propine

2-iodophenylsulfonamide

P(C6H5)3

→

phenylsulfonamide

المذيبات

dimethylformamide

triethylamine

ظروف التفاعل

المعالجة

1. 1
   أخرىis completely reacted
2. 2
   ترشيحThe reaction mixture is filtered
3. 3
   تركيزthe residue is concentrated in vacuo
4. 4
   أخرىThe precipitate is isolated
5. 5
   أخرىdried
6. 6
   أخرىRecrystallisation from ethyl acetate/hexane

الإجراء التجريبي

To a solution of 28.3 g (0.1 mole) of 2-iodophenylsulfonamide in 350 ml of dimethylformamide and 100 ml of triethylamine are added 1.0 g of palladium dichloro-bis(triphenylphosphite) complex, PdCl2 [P(C6H5)3 ]2, and 0.5 g of copper(I) iodide (CuI). Gaseous propine is then introduced into this solution until the starting material is completely reacted. The reaction mixture is filtered and the residue is concentrated in vacuo and then taken up in water. The precipitate is isolated and dried. Recrystallisation from ethyl acetate/hexane yields 15.6 g (80%) of 2-propyn-1-yl)phenylsulfonamide with a melting point of 147°-149° C.

المصدر