تفاعل #48328

معادلة التفاعل

Methylcyclobutanone

THF

allylmagnesium bromide

water

→

1-Allyl-3-methylcyclobutanol

المردود 46.9%

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted
2. 2
   تجفيفThe combined organic extracts were dried over MgSO4
3. 3
   أخرىevaporated
4. 4
   أخرىpurified via glass col

الإجراء التجريبي

Methylcyclobutanone (3.200 g, 38.043 mmol) was dissolved in 200 ml THF and allylmagnesium bromide (190.21 ml, 190.21 mmol) was added in one portion. The mixture was stirred for 4 h at RT, hydrolyzed with water and extracted. The combined organic extracts were dried over MgSO4 and evaporated and purified via glass col. Chrom. (25-75% hex. in EtOAc). 1-Allyl-3-methylcyclobutanol (2.250 g, 46.9% yield) was obtained as a mixture of cis-trans isomers approx 4:1 (where the major compound is the one Me-cis to OH) based on NMR.

المصدر