تفاعل #481827

معادلة التفاعل

alcohol

2,3-Dihydro-1,4-benzodioxin-6-ol

NaH

iodomethane

→

6-Methoxy-2,3-dihydro-1,4-benzodioxin

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe DMF is then evaporated
2. 2
   غسيلWashing with ethyl acetate and with water
3. 3
   أخرىthe two phases are separated
4. 4
   تجفيفThe combined organic phases are dried over MgSO4
5. 5
   أخرىthe solvent is evaporated
6. 6
   أخرىThe oil obtained
7. 7
   أخرىis purified on a silica column (eluant: PE/AcOEt 8/2), which
8. 8
   أخرىto be obtained

الإجراء التجريبي

3 g (18.05 mmol) of the alcohol obtained in Step A are dissolved in 10 ml of DMF in a flask. 2 eq. of NaH (60% in oil) are added slowly and allowed to act for 30 minutes under an inert atmosphere. 2 eq. of iodomethane are then added. The mixture is stirred for 2 hours; the DMF is then evaporated. Washing with ethyl acetate and with water is carried out and the two phases are separated. The combined organic phases are dried over MgSO4 and the solvent is evaporated. The oil obtained is purified on a silica column (eluant: PE/AcOEt 8/2), which allows the pure title product to be obtained.

المصدر