تفاعل #4816

معادلة التفاعل

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىto react together at room temperature for 48 hrs
2. 2
   أخرىthe mixture was triturated in anydrous ether overnite
3. 3
   أخرىThe solid was isolated by filtration under a nitrogen atmosphere
4. 4
   غسيلthoroughly washed with anhydrous ether
5. 5
   تجفيفAfter drying in vacuo over calcium sulfate at room temperature
6. 6
   أخرى2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

الإجراء التجريبي

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

المصدر