تفاعل #480776

معادلة التفاعل

Meldrum's acid

methyl orthoformate

3-Hydroxy-4-methoxyaniline

→

5-((3-hydroxy-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

المردود 82.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was heated
2. 2
   درجة الحرارةat reflux for 15 minutes
3. 3
   درجة الحرارةAfter cooling
4. 4
   ترشيحThe precipitate was collected by filtration
5. 5
   غسيلwashed with methyl orthoformate
6. 6
   أخرىdried under vacuum

الإجراء التجريبي

A solution of Meldrum's acid (32 g, 22.2 mmol)in methyl orthoformate (200 ml) was stirred at 100° C. 3-Hydroxy-4-methoxyaniline (28 g, 20 mmol) was added and the solution was heated at reflux for 15 minutes. After cooling, the mixture was stirred overnight at ambient temperature. The precipitate was collected by filtration, washed with methyl orthoformate followed by ether and dried under vacuum to give 5-((3-hydroxy-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (47.5 g, 82%).

المصدر