تفاعل #47943

معادلة التفاعل

2-(4-penten-1-yl)-4-(trifluoromethyl)pyrimidine

Water

→

title compound

4-[4-(trifluoromethyl)-2-pyrimidinyl]butanal

المذيبات

THF H2O

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture extracted with DCM
2. 2
   غسيلThe organic phase was washed with brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated in vacuo

الإجراء التجريبي

To a solution of 2-(4-penten-1-yl)-4-(trifluoromethyl)pyrimidine (P7, 143 mg) in THF/H2O 5/1 (6.5 mL) were added OsO4 (4% in water, 0.2 mL) and NaIO4 (424 mg). The solution was stirred at r.t. for 30 min. Water was then added and the mixture extracted with DCM. The organic phase was washed with brine, dried over Na2SO4, filtered and evaporated in vacuo to give 91 mg of the title compound as an oil, which was used in the subsequent step without further purification.

المصدر