تفاعل #47900

معادلة التفاعل

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Intermediate 2

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

aniline

→

desired product

6-Benzyl-5,6,7,8-tetrahydro-N-phenylpyrido[4,3-d]pyrimidin-4-amine

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvents were removed under vacuum

الإجراء التجريبي

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (Intermediate 2, 1.0 g, 3.86 mmol) was dissolved in anhydrous acetonitrile (3 mL) and aniline was added (0.39 mL, 4.24 mmol). The mixture was heated at 180° C. for 600 s in a microwave (Emrys Optimizer model, Personal Chemistry). The solvents were removed under vacuum to give the desired product as a beige powder (1.5 g, quant.). The crude product was used as such for the subsequent step.

المصدر