تفاعل #478844

معادلة التفاعل

Ethyl 2-(4-(hydroxymethyl)phenylamino)-6-(2-methoxyphenylamino)-5-nitropyrimidine-4-carboxylate

Ethyl 2-chloro-6-(2-methoxyphenylamino)-5-nitropyrimidine-4-carboxylate

4-aminobenzyl alcohol

diisopropylethylamine

→

title compound

المردود 100.0%

2-(4-((1H-IMIDAZOL-1-YL)METHYL)PHENYLAMINO)-9-(2-METHOXYPHENYL)-8-OXO-8,9-DIHYDRO-7H-PURINE-6-CARBOXAMIDE

المردود 100.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude reaction mixture
2. 2
   أخرىcondensed
3. 3
   أخرىpurified

الإجراء التجريبي

Ethyl 2-(4-(hydroxymethyl)phenylamino)-6-(2-methoxyphenylamino)-5-nitropyrimidine-4-carboxylate. Ethyl 2-chloro-6-(2-methoxyphenylamino)-5-nitropyrimidine-4-carboxylate (See Example 30.A) (0.250 g, 0.710 mmol), 4-aminobenzyl alcohol (0.104 g, 0.852 mmol) and diisopropylethylamine (0.137 g, 1.065 mmol) were reacted according to General Procedure C, except at room temperature and in dimethylformamide (5 mL). The crude reaction mixture was condensed and purified using Biotage chromatography (60-100% ethyl acetate in hexanes) to afford the title compound (0.374 g, >100%). MS (ESI) m/z 440.0 [M+1]+.

المصدر