تفاعل #478779

معادلة التفاعل

K2CO3

methyl 3-(methylsulfinyl)benzoate

2,2,2-trifluoroacetamide

magnesium oxide

iodobenzene diacetate

→

title compound

المردود 74.2%

Methyl 3-(S-methylsulfonimidoyl)benzoate

المردود 74.2%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe mixture was filtered
2. 2
   ترشيحpast filter agent (Celite)
3. 3
   غسيلrinsed with chloroform, and rotary evaporated
4. 4
   workup.DISSOLUTIONThe sample was dissolved in EtOAc
5. 5
   غسيلwashed with brine/dilute HCl, brine
6. 6
   تجفيفdried with anhydrous Na2SO4 and rotary evaporated
7. 7
   workup.DISSOLUTIONThe yellow-orange oil was dissolved in 60 ml MeOH
8. 8
   أخرىThe MeOH filtrate was decanted from the solids, which
9. 9
   غسيلwere then rinsed with MeOH and EtOAc
10. 10
    workup.ADDITIONthe aqueous layer diluted
11. 11
    workup.ADDITIONby adding H2O
12. 12
    غسيلThe aqueous layer was washed with 30% EtOAc in hexane
13. 13
    استخلاصThe aqueous layer was extracted with CHCl3
14. 14
    غسيلthe combined CHCl3 layers washed with brine
15. 15
    تجفيفdried with anhydrous Na2SO4
16. 16
    أخرىrotary evaporated

الإجراء التجريبي

A solution of methyl 3-(methylsulfinyl)benzoate (3.23 g, 16.3 mmol), 2,2,2-trifluoroacetamide (3.69 g, 32.6 mmol), magnesium oxide (1.97 g, 48.9 mmol), rhodium(II)acetate dimer (0.18 g, 0.408 mmol), and iodobenzene diacetate (7.88 g, 24.5 mmol) in 150 ml dichloromethane was stirred at room temperature. After 16 hours, the mixture was filtered past filter agent (Celite), rinsed with chloroform, and rotary evaporated. The sample was dissolved in EtOAc, washed with brine/dilute HCl, brine, dried with anhydrous Na2SO4 and rotary evaporated. The yellow-orange oil was dissolved in 60 ml MeOH, K2CO3 (6.76 g, 48.9 mmol) added, and the mixture stirred at room temperature for 12 minutes. The MeOH filtrate was decanted from the solids, which were then rinsed with MeOH and EtOAc. The pH of the combined organic filtrates were adjusted to pH 2 using 4% HCl, then the aqueous layer diluted by adding H2O. The aqueous layer was washed with 30% EtOAc in hexane, then the pH adjusted to pH 9 with saturated Na2CO3. The aqueous layer was extracted with CHCl3, the combined CHCl3 layers washed with brine, dried with anhydrous Na2SO4 and rotary evaporated to give the title compound as a light tan solid (2.58 g, 74%).

المصدر