تفاعل #47875

معادلة التفاعل

7-benzylamino-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine

heptyl amine

pentanol

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7-benzylamino-5-heptylamino-3-isopropylpyrazolo[4,3-d]pyrimidine

المردود 60.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated to dryness in vacuo
2. 2
   أخرىchromatographed on silica gel
3. 3
   workup.ADDITIONThe mixture of chloroform/acetone/heptane (1:1:1)

الإجراء التجريبي

The mixture 85.6 mg of 7-benzylamino-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine XVI, 0.21 mL of heptyl amine and 1 mL of pentanol was heated at 125° C. for 12 hours. The reaction mixture was evaporated to dryness in vacuo and then chromatographed on silica gel. The mixture of chloroform/acetone/heptane (1:1:1) was used as a mobile phase. Yield=60%; white syrupy; MS (ES+): 381.0 (100%, M+H+). 1H-NMR (300 MHz, CDCl3): 0.86 t (3H, J=6.6 Hz), 1.22-1.36 m (12H), 1.56 m (2H), 1.64 m (2H), 3.12 sept (1H, J=7.1 Hz), 3.41 d (2H, J=5.2 Hz), 4.79 bs (2H), 7.19-7.35 m (5H), 7.60 s (1H).

المصدر