تفاعل #4786

معادلة التفاعل

6-methyl-4-(3-nitrophenyl)-5-phthalimidomethyl-2-phenylpyrimidine

hydrazine monohydrate

→

5-aminomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

المردود 22.8%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 6 hours
2. 2
   ترشيحAfter filtering off the insolubles
3. 3
   workup.ADDITIONthe filtrate was poured into a suspension of chloroform (200 ml) and water (300 ml)
4. 4
   أخرىThe organic layer was separated
5. 5
   غسيلwashed with aqueous sodium chloride
6. 6
   تجفيفdried over magnesium sulfate
7. 7
   أخرىThe solvent was evaporated in vacuo
8. 8
   أخرىthe resulting crystals were recrystallized from ethanol

الإجراء التجريبي

A suspension of 6-methyl-4-(3-nitrophenyl)-5-phthalimidomethyl-2-phenylpyrimidine (6.9 g) and hydrazine monohydrate (0.8 g) in ethanol (140 ml) was refluxed for 6 hours. After filtering off the insolubles, the filtrate was poured into a suspension of chloroform (200 ml) and water (300 ml) under stirring. The organic layer was separated, washed with aqueous sodium chloride and dried over magnesium sulfate. The solvent was evaporated in vacuo and the resulting crystals were recrystallized from ethanol to give 5-aminomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.12 g).

المصدر