تفاعل #4785

معادلة التفاعل

6-methyl-5-(1-piperazinylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine dihydrochloride

dichloromethane

2-furoyl chloride

→

6-methyl-5-[4-(2-furoyl)piperazin-1-ylmethyl]-4-(3-nitrophenyl)-2-phenylpyrimidine

المردود 97.5%

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction mixture was concentrated under reduced pressure
2. 2
   ترشيحThe precipitate was collected by filtration
3. 3
   غسيلwashed with water
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

To a mixture of 6-methyl-5-(1-piperazinylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine dihydrochloride (1 g), dichloromethane (10 ml) and triethylamine (0.48 g), was added 2-furoyl chloride (0.31 g) at 5° C. under ice cooling. After stirring for 1 hour at the same temperature, the reaction mixture was concentrated under reduced pressure. The residue was suspended in water and adjusted to pH=9 with aqueous saturated sodium hydrogen carbonate. The precipitate was collected by filtration, washed with water and dried in vacuo to give 6-methyl-5-[4-(2-furoyl)piperazin-1-ylmethyl]-4-(3-nitrophenyl)-2-phenylpyrimidine (1.02 g).

المصدر