تفاعل #47848

معادلة التفاعل

4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

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title compound

المردود 85.6%

2-(methylsulfonyl)thieno[2,3-d]pyrimidine

المردود 85.6%

المذيبات

ethyl alcohol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas bubbled for 5 minutes
2. 2
   workup.ADDITIONTo this solution was added 10% palladium on activated charcoal (15 g)
3. 3
   أخرىTo the resulting mixture was bubbled hydrogen gas over night
4. 4
   ترشيحThe reaction mixture was filtered through Celite
5. 5
   تركيزThe filtrate was concentrated

الإجراء التجريبي

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

المصدر