تفاعل #47843

معادلة التفاعل

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

benzylamine

sodium iodide

→

titled compound

المردود 44.0%

1-benzylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

المردود 44.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby refluxing for 6 hrs
2. 2
   غسيلThe resulting mixture washed with saturated saline
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over anhydrous MgSO4
6. 6
   تركيزconcentrated under a reduced pressure
7. 7
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (120 mg, 0.32 mmol) obtained in Example 18 was dissolved in THF (10 mL), and benzylamine (102.87 mg, 0.11 mL, 0.93 mmol) and sodium iodide (9.60 mg, 0.06 mmol) were added thereto, followed by refluxing for 6 hrs. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 56 mg of the titled compound (yield: 44%).

المصدر