تفاعل #47842

معادلة التفاعل

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

morpholine

→

titled compound

المردود 83.0%

6-methoxy-1-morpholine-4-yl-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

المردود 83.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent was removed under a reduced pressure
2. 2
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (10 mg, 0.40 mmol) obtained in Example 18 was dissolved in THF (15 mL), and morpholine (175.01 mg, 0.18 mL, 2.01 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 126 mg of the titled compound (yield: 83%).

المصدر