تفاعل #47839

معادلة التفاعل

1-Amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester

1-amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

acetyl chloride

triethylamine

→

titled compound

المردود 47.0%

1-acetylamino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

المردود 47.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىat 0° C
2. 2
   غسيلwashed with saturated saline
3. 3
   استخلاصextracted with dichloromethane
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over anhydrous MgSO4
6. 6
   تركيزconcentrated under a reduced pressure
7. 7
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.07 mmol) prepared in Example 21 was dissolved in dichloromethane (10 mL), and acetyl chloride (30.15 mg, 0.37 mmol) and triethylamine (40 mg, 0.37 mmol) were added thereto in order at 0° C. The mixture was stirred for 24 hrs at RT, washed with saturated saline and extracted with dichloromethane. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 15 mg of the titled compound (yield: 45%).

المصدر