تفاعل #47826

معادلة التفاعل

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

المردود 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

المردود 52.0%

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   أخرىThe organic layer was separated
3. 3
   تركيزconcentrated under a reduced pressure
4. 4
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

المصدر