تفاعل #47818

معادلة التفاعل

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

phenylmagnesium chloride

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titled compound

المردود 90.3%

1-hydroxy-1,3-diphenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

المردود 90.3%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىUpon the completion of the reaction
2. 2
   غسيلthe mixture washed with saturated saline
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over anhydrous MgSO4
6. 6
   تركيزconcentrated under a reduced pressure
7. 7
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (350 mg, 0.878 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (0.483 mL, 0.966 mmol) was added thereto, followed by stirring for 3 hrs at 0° C. Upon the completion of the reaction, the mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 378 mg of the titled compound (yield: 90%).

المصدر