تفاعل #47817

معادلة التفاعل

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

p-toluenesulfonic acid

→

titled compound

المردود 62.1%

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

المردود 62.1%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 24 hrs
2. 2
   غسيلThe resulting mixture washed with sodium bicarbonate
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   أخرىThe organic layer was separated
5. 5
   تجفيفdried over anhydrous MgSO4
6. 6
   تركيزconcentrated under a reduced pressure
7. 7
   أخرىThen, the resulting residue was purified by flash chromatography

الإجراء التجريبي

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (2 g, 4.85 mmol) obtained in Example 7 was dissolved in methanol, p-toluenesulfonic acid (92 mg, 0.49 mmol) was added thereto, and refluxed for 24 hrs. The resulting mixture washed with sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 1.2 g of the titled compound (yield: 62%).

المصدر