تفاعل #47801

معادلة التفاعل

compound

2-(3-methoxy-benzyl)-3-oxo-3-phenyl-propionic Acid Ethyl Ester

THF

phenylmagnesium chloride

→

titled compound

المردود 76.0%

1-hydroxy-6-methoxy-1,3-diphenyl-1H-indene-2-carboxylic Acid Ethyl Ester

المردود 76.0%

ظروف التفاعل

المعالجة

1. 1
   غسيلThen, the resulting mixture washed with saturated saline
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   أخرىThe organic layer was separated
4. 4
   تجفيفdried over anhydrous MgSO4
5. 5
   تركيزconcentrated under a reduced pressure
6. 6
   أخرىThe resulting residue was purified by flash chromatography

الإجراء التجريبي

The compound (300 mg, 0.97 mmol) obtained in Step 1 was dissolved in THF and 1.5 equivalents of phenylmagnesium chloride were added thereto, followed by stirring for 1 hr at 0° C. Then, the resulting mixture washed with saturated saline, and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 285 mg of the titled compound (yield: 76%).

المصدر