تفاعل #4780

معادلة التفاعل

5-(1-bromoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

N-methylpiperazine

→

6-methyl-5-[1-(4-methylpiperazin-1-yl)ethyl]-4-(3-nitrophenyl)-2-phenylpyrimidine

المردود 32.4%

المذيبات

isopropylalcohol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 1.5 hours
2. 2
   أخرىThe reaction mixture was evaporated in vacuo
3. 3
   أخرىThe residue was chromatographed on allumina
4. 4
   workup.ADDITIONeluting with a mixture of ethyl acetate and n-hexane (1:20)
5. 5
   workup.ADDITIONThe fractions containing the desired product
6. 6
   تركيزconcentrated in vacuo
7. 7
   أخرىThe residue was crystallized from a mixture of n-hexane and diethyl ether

الإجراء التجريبي

A mixture of 5-(1-bromoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g) and N-methylpiperazine (1.13 g) in isopropylalcohol (15 ml) was refluxed for 1.5 hours. The reaction mixture was evaporated in vacuo. The residue was chromatographed on allumina eluting with a mixture of ethyl acetate and n-hexane (1:20). The fractions containing the desired product were combined and concentrated in vacuo. The residue was crystallized from a mixture of n-hexane and diethyl ether to give 6-methyl-5-[1-(4-methylpiperazin-1-yl)ethyl]-4-(3-nitrophenyl)-2-phenylpyrimidine (0.51 g).

المصدر